Dr. Lloyd M. Davis
Professor of Physics

Center for Laser Applications
University of Tennessee Space Institute, Tullahoma, TN 37388
Phone: (931) 393-7335
Fax: (931) 454-2271
E-mail: ldavis@utsi.edu
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PRESENT STUDENTS:

Major Advisor for:

Justin Crawford, Physics
James Germann, Physics
Jason King, Physics
You Li, Physics
William Robinson, Physics

Committee Member for:

Subhashini Chitta, Mechanical Aerospace, and Biomedical Engineering
Howard Frederick, Physics
Jesse Ogle, Physics
Depak Raijput, Materials Science
Joshua Whitney, Physics
 

 
   
STUDENT THESES AND DISSERTATIONS  

SELECTED PUBLICATIONS:

“Triplet-state investigations of fluorescent dyes at dielectric interfaces using total internal reflection fluorescence correlation spectroscopy,” H. Blom, A. Chmyrov, K. Hassler, L.M. Davis,| and J. Widengren, J. Phys. Chem A, 113, 5554-5566 (2009).

“Single-pulse ultrafast-laser machining of high aspect nano-holes at the surface of SiO2,” Y.V. White, X. Li, Z. Sikorski, L.M. Davis, and W. Hofmeister, Optics Express 16, 14411-14420 (2008).

“Electrokinetic delivery of single fluorescent biomolecules in fluidic nanochannels,” L.M. Davis, B.K. Canfield, X. Li, W.H. Hofmeister, I.P. Lescano-Mendoza, B.W. Bomar, J.P. Wikswo, D.A. Markov, P.C. Samson, C. Daniel, Z. Sikorski, and W. Robinson, in Biosensing, ed. by M. Razeghi and H. Mohseni, Proceedings of SPIE 7035, 70350A, 1-12 (2008).

“Femtosecond micro- and nano-machining of materials for microfluidic applications,” Y.V. White, M. Parrish, X. Li, L.M. Davis, W. Hofmeister, in Nanoengineering: Fabrication, Properties, Optics, and Devices V, ed. by E.A. Dobisz and L.A. Eldada, Proceedings of SPIE 7039, 70390J, 1-10 (2008).

“Engineering the collected field for single-molecule orientation determination,” Z. Sikorski and L.M. Davis, Optics Express 16, 3660-3673 (2008).

“Maximum-likelihood position sensing and actively controlled electrokinetic transport for single-molecule trapping,” L. Davis, Z. Sikorski, W. Robinson, G. Shen, X. Li, B. Canfield, I. Lescano, B. Bomar, W. Hofmeister, J. Germann, J. King, Y. White, and A. Terekhov, in Single-molecule spectroscopy and imaging, ed. by J. Enderlein, Z.K. Gryczynski, R. Erdmann, Proceedings of SPIE 6862, 68620P, 1-10 (2008).

“Fabrication and characterization of nanofluidics device using fused silica for single protein molecule detection,” X. Li, W. Hofmeister, G. Shen, L.M. Davis, and C. Daniel, in Medical Device Materials IV (Proceedings of Materials and Processes for Medical Devices 2007) , ed. by J. Gilbert, ASM International, 2008, pp. 145-150 (2008).

“Engineering of illumination and collection field profiles for single-molecule orientational imaging,” Z. Sikorski and L.M. Davis, in Complex Light and Optical Forces, ed. by D.L. Andrews, E.J. Galvez, G. Nienhuis, Proceedings of SPIE 6483, 64830K, 1-12 (2007).

“Extension of multidimensional microscopy to ultrasensitive applications with maximum-likelihood analysis,” Lloyd M. Davis and Guoqing Shen, in Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XIV, ed. by J.-A. Conchello, C.J. Cogswell, T. Wilson, Proceedings of SPIE 6443, 64430N, 1-12 (2007).

“Single-molecule detection with axial flow into a micrometer-sized capillary,” D.A. Ball, G. Shen, and L.M. Davis, Applied Optics 46, 1157-1164 (2007).

“Accounting for triplet and saturation effects in fluorescence correlation spectroscopy measurements,” L.M. Davis and G.Q. Shen, Current Pharmaceutical Biotechnology 7, 287-301 (2006).

“Saturation effects in fluorescence correlation spectroscopy," L.M. Davis, G.Q. Shen, and D.A. Ball, paper 5700-25, in Multiphoton Microscopy in the Biomedical Sciences, ed. by A. Periasamy, P.T.C. So, Proceedings of SPIE 5700, 128-137 (2005).

“Data reduction methods for application of fluorescence correlation spectroscopy to pharmaceutical drug discovery,” L.M. Davis, P.E. Williams, D.A. Ball, E.D. Matayoshi, and K.M. Swift, Current Pharmaceutical Biotechnology 4, 451-462 (2003); 5, 481-481 (2004)

“Dealing with reduced data acquisition times in fluorescence correlation spectroscopy for HTS applications,” L.M. Davis, D.A. Ball, P.E. Williams, E.D. Matayoshi, and K.M. Swift, in Microarrays and Combinatorial Technologies for Biomedical Applications, ed. by D.V. Nicolau and R. Raghavachari, Proceedings of SPIE 4966, 117-128 (2003).

“Multiplexed analysis using time-resolved near-IR fluorescence for the detection of genomic material,” W.J. Stryjewski, S.A. Soper, S. Lassiter, and L.M. Davis, in Biomedical Nanotechnology Architectures and Applications, ed. by D.J. Bornhop, D.A. Dunn, R.P. Mariella, Jr., C.J. Murphy, D.V. Nicolau, Sr., S. Nie, M. Palmer, R. Raghavachari, Proceedings of SPIE 4626, 201-209 (2002).

“Imaging of single-chromophore molecules in aqueous solution near a fused-silica interface,” L.M. Davis, W.C. Parker, D.A. Ball, J.G.K. Williams, G.R. Bashford, P. Sheaff, R. Eckles, D.T. Lamb, and L.R. Middendorf, in Multiphoton Microscopy in the Biomedical Sciences, ed. by A. Periasamy, P.T.C. So, Proceedings of SPIE 4262, 301-311 (2001).

“Analysis of ultrasensitive fluorescence experiments,” L.M. Davis, Y. Sun, and B. Whitehead, in Advances in Fluorescence Sensing Technology IV, ed. by J.R. Lakowicz, S.A. Soper, R.B.   Thompson, Proceedings of SPIE 3602, 379-390 (1999).

“Computer simulation of gene detection without PCR by single molecule detection,” L.M. Davis, J.G.K. Williams, and D.T. Lamb, in Biomedical Sensors, Fibers, and Optical Delivery Systems, ed. by F. Baldini, N.I. Croitoru, M. Frenz, I. Lundstrom, M. Miyagi, R. Pratesi, O.S. Wolfbeis, Proceedings of SPIE 3570, 282-293 (1999).

“Avalanche detector with ultra-clean response for time-resolved photon counting,’’ A. Spinelli, M. Ghioni, S. Cova, and L.M. Davis, IEEE Journal of Quantum Electronics, 34, 817-821 (1998).

“Monte Carlo simulation of a single molecule detection experiment,” D.H. Bunfield and L.M. Davis, Applied Optics 37, 2315-2326 (1998).

“Single molecule detection for ultrasensitive analysis and separations on microchips,” J.C. Fister III, S.C. Jacobson, L.M. Davis, and J.M. Ramsey, Analytical Chemistry 70, 431-437 (1998).

“Actively quenched single photon avalanche diode for high repetition rate time-gated photon counting,” A. Spinelli, L.M. Davis, and H. Dautet, Review of Scientific Instruments 67, 55-61 (1996).

“Rapid and efficient detection of single chromophore molecules in aqueous solution,” L.Q. Li and L.M. Davis, Applied Optics 34, 3208-3217 (1995).

“Ultrasensitive sub-nanosecond time-gated detection using a single photon avalanche diode,” L.M. Davis and L.Q. Li, in Applications of Photonic Technology, ed. by G.A. Lamppropoulos, J. Chrostowski, and R.M. Measures, pp. 483-488,  Plenum, New York and London (1995).

“The photophysical constants of several fluorescent dyes pertaining to ultrasensitive fluorescence spectroscopy,” S.A. Soper, E.B. Shera, L.M. Davis, H.L. Nutter, and R.A. Keller, Photochemistry and Photobiology 57, 972-977 (1993).

“Single photon avalanche-diode for single-molecule detection,” L.Q. Li and L.M. Davis, Review of Scientific Instruments 64, 1524-1529 (1993).

“Picosecond resolved evolution of laser breakdown in gases,” L.M. Davis, L.Q. Li, and D.R. Keefer, Journal of Physics D: Applied Physics 26, 222-230 (1993).

“Detection and identification of single molecules in solution,” S.A. Soper, L.M. Davis, and E.B. Shera, Journal of the Optical Society of America B: Optical Physics 9, 1761-1769 (1992).

“Use of streak camera for time resolved photon counting fluorimetry,” L.M. Davis and C. Parigger, Measurement Science & Technology 3, 85-90 (1992) 

“Rapid sequencing of DNA based on single molecule detection,” S.A. Soper, L.M. Davis, F.R. Fairfield, M.L. Hammond, C.A. Harger, J.H. Jett, R.A. Keller, B.A. Marrone, J.C. Martin, H.L. Nutter, E.B. Shera, and  D.J. Simpson, in Optical Methods for Ultrasensitive Detection and Analysis: Techniques and Applications, ed. by B.L. Fearey, Proceedings of SPIE 1435, 168-178 (1991).

“Rapid DNA sequencing based upon single molecule detection,” L.M. Davis, F.R. Fairfield, J.H. Hahn, C.A. Harger, J.H. Jett, R.A. Keller, L.A. Krakowski, B.A. Marrone, J.C. Martin, H.L. Nutter, R.L. Ratliff, E.B. Shera, D.J. Simpson, and S.A. Soper, Genetic Analysis – Biomolecular Engineering 8, 1-7 (1991).

“Laser treatment,” J.R. Forwood and L.M. Davis, U.S. Patent 07/551,100 Granted by with U.S. Dept of Commerce (1991).

“Detection of single fluorescent molecules,” E.B. Shera, N.K. Seitzinger, L.M. Davis, R.A. Keller, and S.A. Soper, Chemical Physics Letters 174 (6), 553-557 (1990).

“Einstein-Podolsky-Rosen and Bell's inequality experiments using time and frequency,” L.M. Davis, Physics Letters A 140, 275-279 (1989).

“Atomic response to bichromatic crossed beam fields,” W.M. Ruyten, L.M. Davis, C. Parigger, and D.R. Keefer, in Advances in Laser Sciences-III, ed. by A.C. Tam, J.O. Gole, W.C. Stwalley. American Institute of Physics Proceedings 172, 155-157 (1988).

“Interference between resolvable wavelengths with single photon resolved detection,” L.M. Davis, Physical Review Letters 60, 1258-1261 (1988).

“An experimental investigation of the probe volume of a laser velocimeter,” L.M. Davis, L.M. Smith, and D.R. Keefer, in High Speed Photography, Videography and Photonics V, ed. by H. Johnson, Proceedings of SPIE 832, 83-87 (1987).

“An in situ method for detection of lipid peroxidation effects,” T. Alvager and L.M. Davis, in Prostaglandin and Lipid Metabolism in Radiation Injury, ed. by T.L. Walden Jr., H.N. Hughes, pp. 387-391, Plenum Press, New York (1987).

“Electron-donor properties of the anti-tumor drug amsacrine as studied by fluorescence quenching of DNA-bound ethidium,” L.M. Davis, B.C. Baguley, and J.D. Harvey, Chemico- Biological Interactions 62, 45-58 (1987). 

“Rate-equation simulation of a synchronously pumped dye-laser,” L.M. Davis, J.D. Harvey, and J.M. Peart, Optics Communications 50, 49-55 (1984).

“Thermal hysteresis in acoustic resonators,” L.W. Casperson, L.M. Davis, and J.D. Harvey, Journal of the Acoutical Society of America 71, 1412-1416 (1982).

 

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